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KMID : 0356620030180020227
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Journal of Korean Society of Endocrinology
2003 Volume.18 No. 2 p.227 ~ p.231
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A Case of Pheochromocytoma with Ganglioneuronal Differentiation Producing Vasoactive Intestinal Peptide
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Na Min-A
Kim Sang-Soo
Kim Dong-Uk
Choe Jae-Hun
Lee Tae-Keun
Gong Og-Nyeo
An Jun-Hyeob
Kim Jee-Yeon
Seong Han-Dong
Jeong Cheol-Ho
Son Suk-Man
Kim In-Ju
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Abstract
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Vasoactive intestinal peptide(VIP) is a 28-amino acid peptide, which may cause secretory diarrhea by stimulating the production of adenylate cyclase. Neuroendocrine tumors, secreting vasoactive intestinal peptide (VIP), are almost always of a pancreatic in origin. However, a pheochromocytoma may produce several neuropeptides, containing VIP, as they are considered to be neuroendocrine tumors. A 57-year-old woman, who presented with chronic watery diarrhea, hypokalemia, weight loss and a left adrenal mass, is described. Histologically, the tumor was diagnosed as a pheoch-romocytoma, with ganglioneuronal differentiation, and was histochemically confirmed to produce a vasoactive intestinal polypeptide. A left adrenal VIP-producing pheochromocytoma was successfully resected. After surgery, her diarrhea subsided and the electrolytes, affected neuroendocrine hormone levels, blood pressure and blood sugar level were normalized.
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KEYWORD
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Vasoactive intestinal peptide, VIP, Pheochromocytoma
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